Highly effective and well-tolerated broad-spectrum antibiotic. It is an antibiotic first isolated from Streptomyces venequelae in 1947 but now produced synthetically. | Group of broad spectrum antibiotics and antiprotozoa. The common nitrofurans are furazolidone (AOZ), furaltadone (AMOZ), nitrofurantoin (AHD) and nitrofurazone (SC). Nitrofurans are quickly metabolized in animals but the tissue-bound nitrofuran metabolites are detectable for a long time after administration. AOZ, AMOZ, AHD and SEM (SC), which are commonly tested, are the metabolites of the nitrofuran parent drugs. |
CAP inhibits the synthesis of protein and is mainly bacteriostatic. Mechanism of the action of inhibition includes the interruption of peptide-chain elongation, the blocking of the A site of ribosomes, the misreading of the genetic code or the prevention of the attachment of oligosaccharide side chains to glycoproteins. | Nitrofurans inhibit a number of microbial enzyme systems, including those involved in carbohydrate metabolism, and they also block the initiation of translation. |
• Aplastic anaemia (bone marrow ceases to produce sufficient red and white blood cells, as well as platelets)* • Hypersensitivity reactions, gastrointestinal complaints and neurological complications after long-term treatment Note:* due to therapeutic treatment courses with CAP |
• Carcinogenic • Mutagenic |
Chloramphenicol (41LCMS-C018, -C069, -C070) - LC-MS/MS detection - Highly sensitive and selective – confirmation test - Quantitative (LOD: as low as ppb) - Specimen matrices: meat, feed* and egg* - ISO 17025 accredited for meat specimens (* denotes not accredited) |
Nitrofurans (AMOZ, AOZ, AHD and SC) (41LCMS-C019, -C124) - LC-MS/MS detection - Highly sensitive and selective – confirmation test - Quantitative (LOD: as low as ppb) - Specimen matrices: meat, feed* - ISO 17025 accredited for meat specimens (* denotes not accredited) |